Orthotopic living related donor transplantation of the liver right lobe in the treatment of unresectable bilobular liver metastases from colorectal cancer

Aim. Тo study the treatment result of unresectable liver metastases from colorectal cancer by technique transplantation. Case report. A man, born in 1963, applied to Medical Center “Universal Clinic “Oberig” with a diagnosis rectal adenocarcinoma pT3bN0M1 (hep) G2, synchronous multifocal bilobar lesions, stage IV after laparoscopic extirpation and adjuvant FOLFIRI + Cetuximab polychemotherapy. Following thorough examination patient, decision was made treat transplanting lobe graft donated living related donor (son). On April 12, 2022, patient underwent orthotopic transplantation right lobe. In early postoperative period, developed an acute perforated ulcer small intestine, he therefore reoperated. The period severe, but condition stabilization achieved conservative treatment, on 38th day, recipient discharged hospital satisfactory condition. According control abdominal MRI during follow-up examinations, no signs recurrence or progression were detected, however, 2 isolated metastatic foci lung parenchyma detected bilaterally CT scan chest 11 months donor. Resection performed systemic polychemotherapy prescribed that regard. Based laboratory instrumental examinations 05.05.2023 (CT scan, MRI), there disease recurrence, level carcinoembryonic antigen 1.5 ng/ml. Conclusions. Liver is effective radical method for patients cancer. Transplantation using has advantages over all other methods safe donors highly specialized centers sufficient experience